منابع مشابه
Caspases determine the vulnerability of oligodendrocytes in the ischemic brain.
Although oligodendrocytes (OLGs) are thought to be vulnerable to hypoxia and ischemia, little is known about the detailed mechanism by which these insults induce OLG death. From the clinical viewpoint, it is imperative to protect OLGs as well as neurons against ischemic injury (stroke), because they are the only myelin-forming cells of the central nervous system. Using the Cre/loxP system, we h...
متن کاملExpression and activation of caspases in the brain during epileptogenesis
Temporal lobe epilepsy (TLE) is the most common form of symptomatic epilepsies. TLE is associated with neurodegeneration that can be either the cause or consequence of the underlying pathology or a result of the recurrent spontaneous seizures. Therefore, understanding of the mechanisms of degenerative processes is crucial in designing of new drug therapies for TLE. Caspases are proteolytic enzy...
متن کاملsurvey on the rule of the due & hindering relying on the sheikh ansaris ideas
قاعده مقتضی و مانع در متون فقهی کم و بیش مستند احکام قرار گرفته و مورد مناقشه فقهاء و اصولیین می باشد و مشهور معتقند مقتضی و مانع، قاعده نیست بلکه یکی از مسائل ذیل استصحاب است لذا نگارنده بر آن شد تا پیرامون این قاعده پژوهش جامعی انجام دهد. به عقیده ما مقتضی دارای حیثیت مستقلی است و هر گاه می گوییم مقتضی احراز شد یعنی با ماهیت مستقل خودش محرز گشته و قطعا اقتضاء خود را خواهد داشت مانند نکاح که ...
15 صفحه اولCaspases
U ncontrolled lymphoproliferation is a characteristic feature of lymphomas and leukemias. Nonmalignant lym-phoproliferative diseases are also observed in humans as well as in lpr (lymphoproliferation) and gld (generalized lymphad-enopathy) mice. The discoveries that spontaneous mutations of Fas (APO-1/CD95) or its ligand (FasL) were associated with the lpr and gld phenotypes led to a satisfying...
متن کاملDeath without caspases, caspases without death.
Apoptosis is a conserved cell-death process displaying characteristic morphological and molecular changes including activation of caspase proteases. Recent work challenges the accepted roles of these proteases. New investigations in mice and the nematode Caenorhabditis elegans suggest that there could be caspase-independent pathways leading to cell death. In addition, another type of cell death...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2002
ISSN: 0360-4012,1097-4547
DOI: 10.1002/jnr.10294